CIP System: Used For Critical Cleaning Applications
- May 28, 2023
Bright Pharma Engineering is a leading manufacturer of cutting-edge process equipment for the pharmaceuticals, bio-pharma, healthcare, and cosmetic industries. We prioritize meeting the diverse requirements of our customers by utilizing the latest technology and automation, making the process reliable, user-friendly, and long-lasting. The company, based in Mumbai, Maharashtra, India, offers a wide range of process machinery to cater to its customer’s needs.
CIP or clean-in-place holds immense significance in the pharmaceutical industry, regardless of the setup, be it a drug manufacturing plant, laboratory, or any other pharma operations. The primary focus is on effectively cleaning and sterilizing the equipment on a regular basis to ensure zero contamination and risk of product quality, thereby ensuring that it is safe for patients to consume. Implementing CIP also saves time, as disassembling and assembling the equipment is no longer required for cleaning purposes. However, the incorporation of CIP systems during the design phase of a facility still needs to gain priority to ensure that the cleaning process is seamless and efficient. By doing so, pharmaceutical companies can significantly reduce the risk of contamination, cutting the cost of cleaning, and enhancing the overall quality of the product.
CIP is performed to clean product contact surfaces such as vessels, interconnecting process piping, pumps, and filtration skids without the need for dismantling them. This effective cleaning method has reduced cleaning cycle time and has proven to be reliable, consistent, and beneficial for the entire product life cycle.
An efficient design of the CIP system takes into account all factors of the Sinner’s circle for successful cleaning. The Sinner’s Circle is a conceptual model that defines the four interdependent factors required for efficient and thorough cleaning: chemical, temperature, time, and mechanical action. In addition to these factors, coverage becomes an essential parameter to include for rigorous setups. Coverage refers to the ability of the cleaning solution to reach and clean all surfaces of the equipment. It is necessary to consider all these parameters during the CIP system design to ensure a thorough and effective cleaning process. Such a comprehensive approach is to maintain equipment hygiene and avoid contamination issues.
